Madonna of the Pomegranate.  Painted in 1487 by Sandro Botticelli

During these years, Art was more about families and less about nations so much that Botticelli painted the pomegranate as the biblical apple.  Pomegranate contains at least 12 different types of estrogens some phytoestrogens and some human identical. Nonsteroidal plant estrogens were studied in the early 1930s, with the discovery that pomegranates, soybeans, willows, and dates, contain compounds with structural similarity to estrogens. (1)

Maintaining healthy levels of the reproductive hormones, estrogen and progesterone, can reduce the risk of triggering RA inflammation. 

Shown that there are a greater number of women who develop RA in their joints, with three times as many patients being female versus male; this led researchers to believe that female hormones may contribute to the triggering of RA, making them a risk factor worth considering.  Women who develop RA typically do so somewhere between the ages of 30 and 60 years old. That puts this age range specifically at risk for developing the symptoms associated with RA.  Because of this, it appears that maintaining healthy levels of the reproductive hormones, estrogen and progesterone, can reduce the risk of triggering RA inflammation. That makes doing blood tests and addressing these levels a prospective treatment option for patients with RA.  Once a female has reached and passed the age of menopause, hormone levels aren’t nearly at the same as they were at an earlier age.  It is possible that this lowered hormone level is what causes the onset of this type of arthritis in the joints, and is why this segment of the population experiences this disease more than any others.


Artificial Hormones

Dangers of hormone replacement therapies with estrogens (HT)
The authors of the Women's Health Insitute concluded that risks of HT, including breast cancer and cardiovascular disease, outweighed the benefits of therapy including a reduction of fractures.  However, because these risks are relatively small, it appears to be appropriate to initiate HT for women with both ersomme vasomotor symptoms who are within 10 years of the onset of menopause and are healthy, especially once other therapies have been shown to be ineffective. (2)

* Moderate-severely bothersome vasomotor symptoms are associated with lowered psychological general wellbeing in women at midlife.

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The link between rheumatoid arthritis and osteoporosis

Studies have found an increased risk of bone loss and fracture in individuals with rheumatoid arthritis. Those having RA are at increased risk for osteoporosis for many reasons.

  • the glucocorticoid medications often prescribed for the treatment of rheumatoid arthritis can trigger significant bone loss
  • pain and loss of joint function caused by the disease it can result in inactivity, further increasing osteoporosis risk
  • bone loss in rheumatoid arthritis may occur as a direct result of the disease. The bone loss is most pronounced in areas immediately surrounding the affected joints
  • women, a group already at increased risk for osteoporosis, are more likely than men to have rheumatoid arthritis

    Examples of glucocorticoid drugs include:
    beclomethasone , betamethasone, budesonide, cortisone, dexamethasone, hydrocortisone, methylprednisolone, prednisolone, triamcinolone.  These synthetic glucocorticoids can be more potent than the naturally occurring steroids. They are used to treat many conditions. 

Glucocorticoids, especially low-doses (under 5 mg prednisone/day) plays an essential role in the management of RA and their quick abandonment is inadvisable and counterproductive as low-dose long-term release of glucocorticoids could delay/reduce the use of biological DMARDs in RA. Glucocorticoid therapy also plays a role on gut microbiota of RA patients which is recognized as one of the main drivers in the immune-inflammatory response.  A renewed interest in the research of interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases, with a focus on rheumatoid arthritis, has shown to greatly improve the disease outcome. (1)

Hydrocortisone - Cortisol is a steroid hormone, in the glucocorticoid class of hormones. When used as a medication, it is known as hydrocortisone


How Cortisol Effects Body and Destroy Proteins Dr. Eric Berg DC

Image and Video (aboe)

Stress, Fear, and Injury triggers a combination of signals from both hormones and nerves. These signals cause your adrenal glands to release (natural) hormones, including adrenaline and cortisol.  The result is an increase in heart rate and energy as part of the fight-or-flight response.(2)  Being in a constant state of stress produces too much cortisol which eventually results in muscle weakness, high blood pressure, mood swings (anxiety, depression or irritability), rapid weight gain (face, chest, and abdomen), skin changes (bruises and purple stretch marks), and osteoporosis.

"Calcium is loss in the urine with high levels of cortisol.  The calcium absorption is decreased through the blocking of the Vitamin D receptor.  When you go through high levels of stress in your life, your Vitamin D level goes down because cortisol  blocks the receptor so you can't absorb Vitamin D.  There's a lot of people that get Sun and still have low Vitamin D which is probably because of high cortisol." ~Dr. Eric Berg DC

Cortisol Highlights

Helps the body deal with stress

Suppresses immune system
-Inhibits thymus gland

Raise blood glucose levels
-Stimulates protein catabolism inhibits protein anabolism
-Resulting amino acids used for gluconeogenesis

-Stimulates lipolysis
-Glycerol used for gluconeogenesis



-Inhibit series 2 prostaglandins
-Decreases number of white blood cells
-Inhibits release of histamine from mast cells

Maintenance of vascular tone

-Permissive effect on α-1 receptors of blood vessels